Semaglutide has side effects, as do all medications. It is generally well-tolerated.

The most common side-effects reported in clinical trials are:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach pain
• Headache
• Fatigue
• Upset stomach
• Dizziness
• Feeling bloated
• Belching
• Stomach flu
• Heartburn

More serious side-effects include:

• Inflammation of the pancreas
• Potential increased risk of thyroid C-cell tumors
• Gallbladder problems
• Low blood sugar
• Kidney problems
• Serious allergic reactions
• Increased heart rate
• Depression or thoughts of suicide